There are multiple therapeutic strategies to identify disease-modifying agents against protein amyloidosis. For natural compound identification, one source of information comes from epidemiological studies that suggest preventative effects against dementia, alzheimer’s disease, or diabetes may be associated with the diets containing high intake of flavonoids and polyphenolic compounds: The Mediterranean diet, featuring by a high intake of vegetables, fruits, cereals, and olive oil, was reported to be associated with reduced risk for AD and mild cognitive impairment in multiethnic community studies in New York.